This content is intended for healthcare professionals.
An artificial bone used for the "application of dental implants," for more natural bone regeneration
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Natural bone regeneration
By filling into a bone defect or void, cells involved in bone metabolism enter the stomata, leading to degradation of the material and the formation of new bone. In a bone regeneration experiment in dogs, using X-ray diffraction, we confirmed that the new bone formed 6 months after implantation of the device had a structure similar to that of the existing bone.
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Application for dental implants
It is an artificial bone that can be used for bone regeneration treatment by filling bone defects or voids in the maxillary and mandibular bone and alveolar bone. Bone regeneration for the premise of dental implant placement is also included in the scope of application.
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Spill-resistant solid shape
The product is not granular, and it is available as 2 types of sponge-like products (disc shaped and cylindrical). Upon water absorption, its flexibility allows it to be easily deformed and used for molding to bone defects of various shapes.
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Biocompatibility of collagen has been confirmed in studies.
The collagen derived from porcine skin used in this product is similar to that used previously in our medical device, and its biocompatibility has been confirmed in studies.
Nerbridge™*1 has been used to treat many cases of nerve defects for several years since its launch in 2013, and there have been no reports of infections identified as originating from raw materials.
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Japan-made bone substitute material
This product is made in our company, and octacalcium phosphate (OCP) and collagen are also made in Japan.
Bone regeneration by OCP*2 and collagen
About OCP
A composite material of octacalcium phosphate (OCP; Ca8H2(PO4)6･5H2O) and collagen developed through industry–academia joint research.
Evaluation of bone regeneration
Canine alveolar cleft model (left: 6 months after surgery; right: 10 months after surgery)
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A new bone from the OCP/Collagen group indicated X-ray diffraction findings similar to those of the existing canine alveolar cleft bone.
Rat cranial bone defect model (4 weeks and 12 weeks after surgery)
β-TCP/Col and HA/Col were independently prepared by Tohoku University that made the test.*5
The OCP/Collagen group had a significantly higher rate of new bone formation at 12 weeks postoperatively than the other groups.
Visualization of bone regeneration.
Canine alveolar cleft model (immediately after surgery to 6 months after surgery)
Although OCP/Collagen is highly radiolucent and less likely to be imaged immediately after implantation, the radiopaque area spreads as bones regenerate
Evaluation of water absorption
Our experimental data
When 1.0 mL of Bonarc™ is saturated after water absorption, its weight is approximately eight times greater.
References
*1 Nerve regeneration guidance conduit Nerbridge™, US FDA 510(k): Clearance No. K152967/Nerve Cuff
*2 A composite material of octacalcium phosphate (OCP; Ca8H2(PO4)6･5H2O) and collagen developed through industry–academia joint research.
*3 Tanuma Y, et al, Oral Surg Oral Med Oral Pathol Oral Radiol Endod 115: 9-17, 2013
*4･*6 Matsui A, et al, The Cleft Palate Craniofac J 51: 420-430, 2014
*5 Kamakura S, et al, Published online 8 June 2007 in Wiley InterScience. DOI: 10.1002/jbm.a.31332