When medical device surface contacts blood, three systems, complement, platelet and coagulation systems are activated by foreign body recognition. After the complement system activation, C3a is generated and leads to inflammation.
After platelet system and coagulation systems activations, they lead to blood clot by platelet adhesion and plasma coagulation.
The 3 units on SEC ONE SURFACETM can prevent foreign body recognitions when contact with blood.
Hydrophilic unit reduces platelet adhesion, blood clot formation and microbes attachment.
Water repellent unit reduces complement activation.
Hydrophobic unit enhances the adhesiveness and consistent coating thickness on base materials and reduces the polymer elution.
|Appearance||Transparent viscous liquid|
|Polymer design||・Copolymer with Polyethylene glycol acrylate, Alkyl acrylate and Polydimethyl siloxane methacrylate
|Water contact angle||Approximately 50°|
|Sterilized by||Ethylene oxide (ETO)|
|Application to medical device||Intravascular catheter1), Cardiopulmonary bypass circuit component2)|
1) Yuta Takezawa et al.: in vivo, 33, 877-880 (2019)
2) Tomomi Hasegawa et al: Perfusion, 35(8), 826-832 (2020)
|Acute systemic toxicity||ISO10993-11*, **||Negative|
|Intracutaneous injection||ISO10993-10*, **||Negative|
|Implantation for 2 and 4 weeks||ISO10993-6*||Negative|
|Subchronic toxicity for 28-day continuous
* “Guidance for Specific Biological Tests Relevant to the Principles Issued by the Notification Iyakushinhatsu No. 0213001”, Pharmaceutical and Food Safety Bureau, Japanese Ministry of Health, Labour and Welfare, Memorandum Iryokiki-shinsa No. 36, March 19, 2003
** “Good Laboratory Practice Standard Ordinance for Nonclinical Laboratory Studies on Safety of Medical Devices”, Japanese Ministry of Health, Labour and Welfare, Ordinance No. 37, March 23, 2005