Albizia Julibrissin Bark Extract GenemClock™│TOYOBO PRODUCT LINEUP│Cosmetics Ingredients │TOYOBO


Albizia julibrissin bark botanical extract GenemClockTM

  • The albizia julibrissin is commonly referred to as the silk tree because of its beautiful silk thread-like stamen. The leaves of the tree close at night and open in the morning̶, so it named “Nemunoki”, or “Sleeping tree”in Japanese.
    Because of its distinctive “body clock,” the bark of the tree has long been used as a natural remedy for insomnia, which can be caused by disrupted biological rhythm.


Our focus is on the skin’s“ body clock.”

Modern life is stressful. When our body clock is disrupted, our skin’s anti-oxidation systems, barrier functions, and regenerative capabilities degenerate, causing blotches, redness, and dull skin.

Clock genes are the key to improving bad skin.

The skin has its own biological clock which controls the timing of various skin-related gene expressions, enabling the skin to “protect” during the day and “recover” at night. We believed that activating these genes would lead to healthier skin.

Normalizing clock gene rhythms

Abnormalities arise in clock gene bmal rhythms when epidermal keratinocyte suffers from oxidative stress.
GenemClockTM supplementation showed that abnormalities in bmal rhythms can be normalized.

The effect of GenemClockTM

Reduction of skin spots / Reduction of melanin spots

Results suggested that applying GenemClockTM for 8 weeks reduces skin spots.

  • Test sample

Application of 2% GenemClockTM lotion morning and night after washing face

  • Test subjects

3 healthy men and women in their 30s (average age of 33.6)

  • Usage

Application of test sample to half face twice a day.

  • Test period

September 28th - November 22th, 2018 (8 weeks)

Effect on sunburn

  • When GenemClockTM is applied to UV-irradiated skin, some testers were confirmed to have the effect of suppressing skin redness.

  • Test sample

Lotion containing 1% GenemClockTM

  • Usage

Apply test sample to the inside of the upper arm twice a day

  • Test subjects

12 healthy men and women in their 20-30s (average age of 33.8)

  • Test period

May 29th - June 6th, 2019 (9 days)

  Not applied Applied
Erythema degree index one day after irradiation( Δa* value change) 4.9 4.03

Δa* value change = a* value (one day after irradiation)-a* value (before irradiation)

Δa* value change = a* value (one day after irradiation)-a* value (before irradiation)

Inhibition of carbonylation

  • Advanced glycation end products (AGEs) cause dull skin with age. Although keeping a solution of BSA (protein) and glucose at 45℃ for 10 days produces glycation indicating carbonyl groups, we observed an inhibiting effect with GenemClockTM

    Sample Carbonyl substrate density
    Mean S.D
    30%BG 5.35 ±0.08
    GenemClockTM 4.89 ±0.03

    Note: Excluding references to other documents, the data on this website is average measured results taken from measurements carried out at our facilities or outsourced facilities.



  • Outline
Product Name GenemClockTM
Warranty Period One year at room temperature, unopened
Delivery Unit 1kg
Additives No preservatives, coloring, or antioxidants
  • Component
INCI Name Albizia Julibrissin Bark Extract Butylene Glycol Water
Chinese Name 合欢(Albizia Julibrissin)树皮提取物 丁二醇
CAS No. 107-88-0 7732-18-5
  • Specification
Appearance Aqueous solution, Yellow - brown to brown
Odor Faint characteristic odor
Identification (Polyphenols) Qualitative reaction
Solid content ≧ 0.9%
Heavy metal ≦ 20ppm
Arsenic ≦ 2 ppm
Total bacteria count ≦ 100 CFU/g
Yeast and Mold ≦ 100 CFU/g
E. coli Negative